motilin receptor (mtlr_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Motilin receptors motilin receptor
GENE
MLNR (GPR38, MTLR, MTLR1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Motilin receptor, G-protein coupled receptor 38
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
S
|
P
|
W
|
N
|
G
|
S
|
D
|
G
|
10 |
P
|
E
|
G
|
A
|
R
|
E
|
P
|
P
|
W
|
P
|
20 |
A
|
L
|
P
|
P
|
C
|
D
|
E
|
R
|
R
|
C
|
30 |
TM1 | |||||||||
S
|
P
|
F
|
P
|
L
|
G
|
A
|
L
|
V
|
P
|
40 |
V
|
T
|
A
|
V
|
C
|
L
|
C
|
L
|
F
|
V
|
50 |
V
|
G
|
V
|
S
|
G
|
N
|
V
|
V
|
T
|
V
|
60 |
ICL1 | |||||||||
M
|
L
|
I
|
G
|
R
|
Y
|
R
|
D
|
M
|
R
|
70 |
TM2 | |||||||||
T
|
T
|
T
|
N
|
L
|
Y
|
L
|
G
|
S
|
M
|
80 |
A
|
V
|
S
|
D
|
L
|
L
|
I
|
L
|
L
|
G
|
90 |
L
|
P
|
F
|
D
|
L
|
Y
|
R
|
L
|
W
|
R
|
100 |
ECL1 | TM3 | ||||||||
S
|
R
|
P
|
W
|
V
|
F
|
G
|
P
|
L
|
L
|
110 |
C
|
R
|
L
|
S
|
L
|
Y
|
V
|
G
|
E
|
G
|
120 |
C
|
T
|
Y
|
A
|
T
|
L
|
L
|
H
|
M
|
T
|
130 |
A
|
L
|
S
|
V
|
E
|
R
|
Y
|
L
|
A
|
I
|
140 |
ICL2 | |||||||||
C
|
R
|
P
|
L
|
R
|
A
|
R
|
V
|
L
|
V
|
150 |
TM4 | |||||||||
T
|
R
|
R
|
R
|
V
|
R
|
A
|
L
|
I
|
A
|
160 |
V
|
L
|
W
|
A
|
V
|
A
|
L
|
L
|
S
|
A
|
170 |
G
|
P
|
F
|
L
|
F
|
L
|
V
|
G
|
V
|
E
|
180 |
ECL2 | |||||||||
Q
|
D
|
P
|
G
|
I
|
S
|
V
|
V
|
P
|
G
|
190 |
L
|
N
|
G
|
T
|
A
|
R
|
I
|
A
|
S
|
S
|
200 |
P
|
L
|
A
|
S
|
S
|
P
|
P
|
L
|
W
|
L
|
210 |
S
|
R
|
A
|
P
|
P
|
P
|
S
|
P
|
P
|
S
|
220 |
G
|
P
|
E
|
T
|
A
|
E
|
A
|
A
|
A
|
L
|
230 |
F
|
S
|
R
|
E
|
C
|
R
|
P
|
S
|
P
|
A
|
240 |
TM5 | |||||||||
Q
|
L
|
G
|
A
|
L
|
R
|
V
|
M
|
L
|
W
|
250 |
V
|
T
|
T
|
A
|
Y
|
F
|
F
|
L
|
P
|
F
|
260 |
L
|
C
|
L
|
S
|
I
|
L
|
Y
|
G
|
L
|
I
|
270 |
G
|
R
|
E
|
L
|
W
|
S
|
S
|
R
|
R
|
P
|
280 |
ICL3 | TM6 | ||||||||
L
|
R
|
G
|
P
|
A
|
A
|
S
|
G
|
R
|
E
|
290 |
R
|
G
|
H
|
R
|
Q
|
T
|
V
|
R
|
V
|
L
|
300 |
L
|
V
|
V
|
V
|
L
|
A
|
F
|
I
|
I
|
C
|
310 |
W
|
L
|
P
|
F
|
H
|
V
|
G
|
R
|
I
|
I
|
320 |
ECL3 | TM7 | |||||||||
Y
|
I
|
N
|
T
|
E
|
D
|
S
|
R
|
M
|
M
|
|
330 |
Y
|
F
|
S
|
Q
|
Y
|
F
|
N
|
I
|
V
|
A
|
340 |
L
|
Q
|
L
|
F
|
Y
|
L
|
S
|
A
|
S
|
I
|
350 |
H8 | |||||||||
N
|
P
|
I
|
L
|
Y
|
N
|
L
|
I
|
S
|
K
|
360 |
K
|
Y
|
R
|
A
|
A
|
A
|
F
|
K
|
L
|
L
|
370 |
C-term | |||||||||
L
|
A
|
R
|
K
|
S
|
R
|
P
|
R
|
G
|
F
|
380 |
H
|
R
|
S
|
R
|
D
|
T
|
A
|
G
|
E
|
V
|
390 |
A
|
G
|
D
|
T
|
G
|
G
|
D
|
T
|
V
|
G
|
400 |
Y
|
T
|
E
|
T
|
S
|
A
|
N
|
V
|
K
|
T
|
410 |
M
|
G
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
motilin
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page